It’s a pretty sure bet that anyone who survived high school biology has heard about the Miller-Urey experiment that supported the hypothesis that the chemistry of life could arise from Earth’s primordial atmosphere. It was literally “lightning in a bottle,” with a mix of gases like methane, ammonia, hydrogen, and water in a closed-loop glass apparatus and a pair of electrodes to provide a spark to simulate lightning lancing across the early prebiotic sky. [Miller] and [Urey] showed that amino acids, the building blocks of protein, could be cooked up under conditions that existed before life began.

Fast forward 70 years, and Miller-Urey is still relevant, perhaps more so as we’ve extended our reach into space and found places with conditions similar to those on early Earth. This modified version of Miller-Urey is a citizen science effort to update the classic experiment to keep up with those observations, plus perhaps just enjoy the fact that it’s possible to whip up the chemistry of life from practically nothing, right in your own garage.

[Markus Bindhammer]’s setup is similar to [Miller] and [Urey]’s in a lot of ways, but differs mainly by using plasma as the energy input, rather than a simple electrical discharge. [Markus] doesn’t expand on his reasoning for using plasma other than the practical consideration of it being hot enough to oxidize nitrogen inside the apparatus, providing the anoxic environment needed. The plasma discharge is controlled by a microcontroller and MOSFETs, to keep the electrodes from melting. Also, rather than methane and ammonia, the raw ingredient here is a formic acid solution, because the spectroscopic signature of formic acid has been detected in space, and because it has interesting chemistry that can potentially lead to the production of amino acids.

Unfortunately, while the apparatus and experimental procedure are fairly simple, quantifying the results requires some specialized equipment. [Markus] will be sending his samples off for analysis, so we don’t yet know what the experiment will show. But we love the setup here, which just goes to show that even the greatest experiments are worth repeating, because you never know what you’re going to find.

It sounds like an overly complicated method a supervillain would use to slowly and painfully eliminate enemies — a chamber with variable oxygen concentration. This automated environmental chamber isn’t for torturing suave MI6 agents, though; rather, it enables cancer research more-or-less on the cheap.

Tasked with building something to let his lab simulate the variable oxygen microenvironments found in some kinds of tumors, [RyanM415] first chose a standard lab incubator as a chamber to mix room air with bottled nitrogen. With a requirement to quickly vary the oxygen concentration from the normal 21% down to zero, he found that the large incubator took far too long to equilibrate, and so he switched to a small acrylic box. Equipped with a mixing fan, the smaller chamber quickly adjusts to setpoints, with an oxygen sensor providing feedback and controlling the gas valves via a pair of Arduinos. It’s quite a contraption, with floating ball flowmeters and stepper-actuated variable gas valves, but the results are impressive. If it weren’t for the $2000 oxygen sensor, [RyanM145] would have brought the whole project in for $500, but at least the lab can use the sensor elsewhere.

Modern biology and chemistry labs are target-rich environments for hacked instrumentation. From DIY incubators to cheap electrophoresis rigs, we’ve got you covered.

If you had a choice between going to your boss and asking for funds for a new piece of gear, would you rather ask for $3000 to buy off-the-shelf, or $200 for the parts to build the same thing yourself? Any self-respecting hacker knows the answer, and when presented with an opportunity to equip his lab with a new DIY syringe pump for $200, [Dr. D-Flo] rose to the challenge.

The first stop for [Dr. D-Flo] was, naturally, Hackaday.io, which is where he found [Naroom]’s syringe pump project. It was a good match for his budget and his specs, but he needed to modify some of the 3D printed parts a little to fit the larger syringes he intended to use. The base is aluminum extrusion, the drive train is a stepper motor spinning threaded rod and a captive nut in the plunger holders, and an Arduino and motor shield control everything. The drive train will obviously suffer from a fair amount of backlash, but this pump isn’t meant for precise dispensing so it shouldn’t matter. We’d worry a little more about the robustness of the printed parts over time and their compatibility with common lab solvents, but overall this was a great build that [Dr. D-Flo] intends to use in a 3D food printer. We look forward to seeing that one.

It’s getting so that that you can build almost anything for the lab these days, from peristaltic pumps to centrifuges. It has to be hard to concentrate on your science when there’s so much gear to make.

A first-time visitor to any bio or chem lab will have many wonders to behold, but few as captivating as the magnetic stirrer. A motor turns a magnet which in turn spins a Teflon-coated stir bar inside the beaker that sits on top. It’s brilliantly simple and so incredibly useful that it leaves one wondering why they’re not included as standard equipment in every kitchen range.

But as ubiquitous as magnetic stirrers are in the lab, they generally come in largish packages. [BantamBasher135] needed a much smaller stir plate to fit inside a spectrophotometer. With zero budget, he retrofitted the instrument with an e-waste, Arduino-controlled magnetic stirrer.

The footprint available for the modification was exceedingly small — a 1 cm square cuvette with a flea-sized micro stir bar. His first stab at the micro-stirrer used a tiny 5-volt laptop fan with the blades cut off and a magnet glued to the hub, but that proved problematic. Later improvements included beefing up the voltage feeding the fan and coming up with a non-standard PWM scheme to turn the motor slow enough to prevent decoupling the stir bar from the magnets.

[BantamBasher135] admits that it’s an ugly solution, but one does what one can to get the science done. While this is a bit specialized, we’ve featured plenty of DIY lab instruments here before. You can make your own peristaltic pump or even a spectrophotometer — with or without the stirrer.

[via r/Arduino]

Laying hands on the supplies for most hacks we cover is getting easier by the day. A few pecks at the keyboard and half a dozen boards or chips are on an ePacket from China to your doorstep for next to nothing. But if hacking life is what you’re into, you’ll spend a lot of time and money gathering the necessary instrumentation. Unless you roll your own mini genetic engineering lab from scratch, that is.

Taking the form of an Arduino mega-shield that supports a pH meter, a spectrophotometer, and a PID-controlled hot plate, [M. Bindhammer]’s design has a nice cross-section of the instruments needed to start biohacking in your basement. Since the piggybacks on an Arduino, all the data can be logged, and decisions can be made based on the data as it is collected. One example is changing the temperature of the hot plate when a certain pH is reached. Not having to babysit your experiments could be a huge boon to the basement biohacker.

Biohacking is poised to be the next big thing in the hacking movement, and [M. Bindhammer]’s design is far from the only player in the space. From incubators to peristaltic pumps to complete labs in a box, the tools to tweak life are starting to reach critical mass. We can’t wait to see where these tools lead.

Controlling the pH level of a solution is usually a tedious task. Adding an acid or base to the solution will change the pH, but manually monitoring the levels and adding the correct amount isn’t fun. [Reza] rigged up an automated pH controller to keep a solution’s pH steady.

The build uses an Arduino with a LCD shield, screw terminal shields, and [Reza]‘s own pH shield attached. A peristaltic pump is used to pump the pH down acid into the solution. This type of pump isolates the fluid from the pump parts, preventing contamination of the solution. The pump is controlled using a PowerSwitch Tail, allowing the Arduino to control the flow of fluid.

An Omega pH probe is used to read the pH level. [Reza]‘s open source firmware has support for calibrating the probe to ensure accurate readings. Once it’s set up, the screen displays the pH level and the current state of the system. The pump is enabled when the pH rises out of the desired range.

After the break, check out a video walk through of the device.

This sort of flying contraption seems more suited for indoor use. Well, except for the fire hazard presented by building an Android controlled hydrogen blimp. The problems we often see with quadcopters come into play when a motor wire comes loose and the thing goes flying off in a random direction. Loosing a motor on this airship will be no big deal by comparison.

Because the build relies on the buoyancy of the gas, light-weight components are the name of the game. The frame of the chassis is built from balsa wood. It supports two tiny DC motors which are almost indistinguishable in the image above. An Arduino nano and wireless receiver monitor commands from the transmitter and drive the propellers accordingly.

You may have noticed that we categorized this one as a chemistry hack. That’s because [Btimar] generated the hydrogen himself. He used an Erlenmeyer flask with a spout for the chemical reaction. After placing several heat sinks and other scraps of solid aluminum in the flask he poured on the lye solution. This generates the H2 but you need to keep things cool using ice to keep the reaction from getting out of control. We’re going to stick with helium filled blimps for the time being!

See this beast flying around [Btimar's] living room in the clip after the break.