In a trial run by Verve Therapeutics, a Cambridge–based biotech company, researchers discovered that a single infusion of a gene-editing treatment called VERVE-101 was able to reduce cholesterol levels in patients. This treatment was tested in individuals with hereditary conditions that made them susceptible to developing clogged arteries and heart attacks. Scientists were able to use CRISPR editing techniques to tweak liver gene cells. The researchers “turned off” a cholesterol-raising gene called PCSK9, which is found in the liver, in order to lower LDL-C — sometimes called "bad" cholesterol — which causes plaque to build up in arteries in the first place.

PCSK9 was lowered by as much as 84 percent in the cohorts that received higher infusion rates of the treatment. At those higher treatment doses, Verve scientists said that the reduction of those LDL-C-related proteins lasted 2.5 years in previous studies on primates.

Verve Therapeutics

From a clinical standpoint, this gene editing therapy has the potential to disrupt the current standard treatment for high cholesterol. The current go-to's include prescription statins and PCSK9 inhibitors, but they require strict adherence and can have bad side effects like muscle pain and memory loss.

CRISPR, while seemingly miraculous, is a long way from replacing daily medications though. According to Nature, two of the 10 participants in the study suffered from a “cardiovascular event” that coincided with the infusion. Verve says one was not related to the treatment at all and the second was “potentially related to treatment due to proximity to dosing.” The use of a gene-editing technology will always carry some risk because the edits could occur elsewhere in the genome.

Before a single infusion therapy for high cholesterol can reach consumers, the FDA mandates that the treatment will need to be studied for up to 15 years. Verve recently received FDA clearance for an Investigational New Drug Application for VERVE-101, meaning that the company can begin to conduct trials in the US. The current trials in New Zealand and the United Kingdom will look for willing clinical trial participants to expand the study.

Synex Medical, a Toronto-based biotech research firm backed by Sam Altman (the CEO of OpenAI), has developed a tool that can measure your blood glucose levels without a finger prick. It uses a combination of low-field magnets and low-frequency radio waves to directly measure blood sugar levels non-invasively when a user inserts a finger into the device.

The tool uses magnetic resonance spectroscopy (MRS), which is similar to an MRI. Jamie Near, an Associate Professor at the University of Toronto who specializes in the research of MRS technology told Engadget that, “[an] MRI uses magnetic fields to make images of the distribution of hydrogen protons in water that is abundant in our body tissues. In MRS, the same basic principles are used to detect other chemicals that contain hydrogen.” When a user’s fingertip is placed inside the magnetic field, the frequency of a specific molecule, in this case glucose, is measured in parts per million. While the focus was on glucose for this project, MRS could be used to measure metabolites, according to the Synex, including lactate, ketones and amino acids.

Synex Medical

Matthew Rosen, a Harvard physicist whose research spans from fundamental physics to bioimaging in the field of MRI, told Engadget that he thinks the device is “clever” and “a great idea.” Magnetic resonance technology is a common technique used for chemical analysis of compounds, however, traditional resonance technologies operate at high magnetic fields and they're very expensive.

Synex found a way to get clear readings from low magnetic fields. “They’ve overcome the challenges really by developing a method that has high sensitivity and high specificity,” Rosen says. “Honestly, I have been doing magnetic resonance for thirty years. I never thought people could do glucose with a benchtop machine… you could do it with a big machine no problem.”

Professor Andre Simpson, a researcher and center director at the University of Toronto also told Engadget that he thinks Synex’s device is the “real deal.” “MRI machines can fit an entire human body and have been used to target molecule concentrations in the brain through localized spectroscopy,” he explained. “Synex has shrunk this technology to measure concentrations in a finger. I have reviewed their white paper and seen the instrument work.” Simpson said Synex’s ability to retrofit MRS technology into a small box is an engineering feat.

As of now, there are no commercially available devices that can measure blood glucose non-invasively. While there are continuous glucose monitors on the market that use microneedles, which are minimally invasive, there is still a risk of infection.

But there is competition in the space for no-prick diagnostics tools. Know Labs is trying to get approval for a portable glucose monitor that relies on a custom-made Bio-RFID sensing technology, which uses radio waves to detect blood glucose levels in the palm of your hand. When the Know Labs device was tested up against a Dexcom G6 continuous glucose monitor in a study, readings of blood glucose levels using its palm sensor technology were “within threshold” only 46 percent of the time. While the readings are technically in accordance with FDA accuracy limits for a new blood glucose monitor, Know Labs is still working out kinks through scientific research before it can begin FDA clinical trials.

Another start-up, German company DiaMonTech, is currently developing a pocket-sized diagnostic device that is still being tested and fine-tuned to measure glucose through “photothermal detection.” It uses mid-infrared lasers that essentially scan the tissue fluid at the fingertip to detect glucose molecules. CNBC and Bloomberg reported that even Apple has been “quietly developing” a sensor that can check your blood sugar levels through its wearables, though the company never confirmed. A scientific director at Synex, Mohana Ray, told Engadget that eventually, the company would like to develop a wearable. But further miniaturization was needed before they could bring a commercial product to market.

Rosen says he isn't sure how the sensor technology can be retrofitted for smartwatches or wearables just yet. But he can imagine a world where these tools complement blood-based diagnostics. “Is it good enough for clinical use? I have to leave that for what clinicians have to say.”

A group of lawmakers from a House of Representatives committee wants Apple, like many Jon Stewart enthusiasts, to explain why its streaming arm abruptly canceled the talk show The Problem With Jon Stewart. The current affairs TV series hosted by Jon Stewart briefly made its debut on Apple TV+ in 2021 but its time on air ended when the show received the ax for a third season, reportedly due to “disagreements” over show topics.

According to Reuters, Lawmakers want to know if the show's coverage and criticism of China has anything to do with the show’s cancellation. The government officials have asked Apple to speak on the issue by Dec 15, 2023. 

In a letter to the tech giant, the House members wrote that while Apple has the right to determine what content it deems appropriate for its platform, “the coercive tactics of a foreign power should not be directly or indirectly influencing these determinations.” This effort is bipartisan, with members from both Republican and Democratic parties affiliated with the House of Representatives' Select Committee on Competition with the Chinese Communist Party.

Roughly 19 percent of Apple sales come from China, with over $72.5 billion in net sales reported for the company’s fiscal 2023, which closed in September. It might make sense that the company would avoid streaming a show with strong political opinions that could impact its bottom line in such a significant way. But the show discussed several hot-button topics, including artificial intelligence and gun control. According to the New York Times, sources familiar with the matter said that, beyond discussions about China, the show’s criticism of topics like artificial intelligence played a role in the decision to cut the show.

A machine learning-based weather prediction program developed by DeepMind researchers called “GraphCast” can predict weather variables over the span of 10 days, in under one minute. In a report, scientists highlight that GraphCast has outperformed traditional weather pattern prediction technologies at a 90% verification rate.

The AI-powered weather prediction program works by taking in “the two most recent states of Earth’s weather,” which includes the variables from the time of the test and six hours prior. Using that data, GraphCast can predict what the state of the weather will be in six hours. 

In practice, AI has already showcased its applicability in the real world. The tool predicted the landfall of Hurricane Lee in Long Island 10 days before it happened, while the traditional weather prediction technologies being used by meteorologists at the time lagged behind. Forecasts made by standard weather simulations can take longer because traditionally, models have to account for complicated physics and fluid dynamics to make accurate predictions.

Not only does the weather prediction algorithm outperform traditional technologies to forecast weather patterns in terms of pace and scale, GraphCast can also predict severe weather events, which includes tropical cyclones and waves of extreme temperatures over regions. And because the algorithm can be re-trained with recent data, scientists believe that the tool will only get better at predicting oscillations in weather patterns that coincide with grander changes that align with climate change.

Soon, GraphCast, or at least the basis of the AI algorithm that powers its predictions, might pop up into more mainstream services. According to Wired, Google might be exploring how to integrate GraphCast into its products. The call for better storm modeling has already paved a path for supercomputers in the space. The NOAA (National Oceanic and Atmospheric Administration) says it has been working to develop models that will provide more accurate readings on when severe weather events might occur and importantly, the intensity forecasts for hurricanes.

Subscriptions to the Headspace app are half off this Black Friday for new and returning customers who have had memberships expire. Starting on November 14 through the 27th, the annual $70 fee will be slashed to $35. Alternatively, you could get a monthly subscription for $6.50 each pay period instead of $13.

A subscription to the mindfulness app will get you access to an entire suite of meditation programming, as well as sounds that can help you focus. But the app isn’t just for stress — it landed a spot on our best sleep app list. Users will also gain access to curated yoga and fitness videos that can help them stick to their fitness goals and in turn, improve overall wellness.

Headspace also offers video content and stress-relieving meditation programs specific for work and school. You can calm your nerves and learn how to connect with your peers by taking the advice of a professional before a presentation if you struggle with public speaking, for example. Or you could follow along with a 7-minute meditation clip to help you decompress after a long day at work. If you're new to meditation, you can start as a beginner through a four-week guided program assembled by a Headspace expert.

If you're navigating change or undergoing a stressful time, this Black Friday deal might be the perfect gateway into meditation and getting extra mental health support. If you're thinking about shopping for the holidays, Engadget has recommended a subscription to Headspace app as a thoughtful gift for teachers, or students alike.

Your Black Friday Shopping Guide: See all of Yahoo’s Black Friday coverage, here. Follow Engadget for Black Friday tech deals. Learn about Black Friday trends on In The Know. Hear from Autoblog’s experts on the best Black Friday deals for your car, garage, and home, and find Black Friday sales to shop on AOL, handpicked just for you.

If you've been waiting for a reason to finally grab a headset to watch 360-degree videos on YouTube or have an exceptionally immersive experience with first-person shooter games, Amazon’s early Black Friday sale on the Meta Quest 2 VR headset might be your gateway into the world of VR. The Quest 2 with 128GB of storage is getting a $50 price cut in a Black Friday pre-sale, bringing it to $250. This record low price, which normally sells for $300, is worth considering, especially since Engadget hailed it as one of the best VR headsets your money can buy.

Despite being an older model, we still consider the Meta Quest 2 the best budget VR headset, and for good reason. Most competitors, including its successor, start at around $500 and can go for as much as $1000. The Quest 2’s screen resolution of 1832x1920 per eye, when coupled with a 90Hz refresh rate, makes activities like gaming a more pleasurable experience. And because the Quest 2 operates using Qualcomm's Snapdragon XR2 processor and packs 6GB of RAM, the device can dabble with more demanding games. If you are already a console user, things like Xbox Cloud gaming pair quite nicely.

The Quest 2 Active bundle, which includes the 128GB headset and accessories for VR workouts, is also on sale on Amazon for $319. But if you want to go big and invest in the 256GB version of the Quest 2, Amazon’s deal on that model will make the device $300, knocking off $50 bucks from its $350 starting point.

Your Black Friday Shopping Guide: See all of Yahoo’s Black Friday coverage, here. Follow Engadget for Black Friday tech deals. Learn about Black Friday trends on In The Know. Hear from Autoblog’s experts on the best Black Friday deals for your car, garage, and home, and find Black Friday sales to shop on AOL, handpicked just for you.

OpenAI is rolling out a new partnership program to collect datasets from third parties that it intends to use to train its AI models. The initiative, OpenAI Data Partnerships, will seek large-scale private and public information that it says is “not already easily accessible online to the public.” The company says the data it will collect doesn't necessarily have to be quantitative or in text formats — the program will also accept images, audio or video.

Notably, the company says it's on the lookout for data on “any topic” and in “any language” so long as it “expresses human intention,” which it likens to long-form essays or transcribed conversations. Human-centric data collected by OpenAI is expected to help the company improve tools like its automatic speech recognition technology which is used to transcribe spoken words. This initiative also lines up with ChatGPT’s recent expansion to support voice queries to engage with users in a conversational manner. Exposing its AI models to more information that teaches it how to hold up human-like conversations will only further improve this feature and other tools that will follow in function.

The model testing conducted throughout the data partnership program will also naturally expand the capabilities of OpenAI’s consumer-facing GPT-4 Turbo, which has been updated to provide users with more complex and meaningful responses. OpenAI says it has already started working with interested organizations, including authoritative bodies like the Icelandic government. Through curated datasets, OpenAI says its working to improve GPT-4’s ability to comprehend queries made in the Icelandic language.

If a private or public organization wants to participate in the program, a representative can submit a form on the company’s website and share information on the data type and size that they intend to share. There are two pathways for datasets. The first is the Open-Source archive, which is ideal for datasets relevant to training language models. However, submissions made to it will be public for anyone to use. Alternatively, OpenAI says a company can submit information through its private dataset pathway which will be funneled to train proprietary AI models, which the company says includes their “foundation models” and “fine-tuned and custom models.” This is recommended for companies or institutions that want to keep their data confidential. But in that same regard, OpenAI says it is not looking for datasets that contain sensitive or personal information.

ChatGPT has already set records for its soaring user base. It has about 100 million weekly active users around the world, meaning privacy will only continue to be a focal point for the tool. Previously, Samsung employees were put in the hot seat for leaking sensitive data to the AI model. While OpenAI claims it does not use data generated by its API to train its models unless a user explicitly submits information through an opt-in form, all eyes will be on how the company handles the data collected through this initiative, especially the private datasets.

The Spotify TV app has been revamped to make the big-screen app experience resemble the popular mobile version of the digital music and podcast streaming service. The home page will have a “Now Playing View” and feature shortcuts to recently played content. The TV app will also recommend new songs and podcasts based on your listening history on the main screen, similar to what you might get on the mobile app.

The TV app home page doesn't just look different. You can now more easily switch between different Spotify accounts. The most recently active profile will always appear in the top right corner of a screen. Say you share a TV in the living room and you want to stop listening to your mom’s playlist – now you can select the profile image of a paired account when you want to switch.

In the past, if you listened to music on your TV through the app, you could only see the next song that was lined up. But now you can use the “Playback Queue” tool to select what you want to play next. Also, you can now turn on dark mode on your TV, meaning you can stream a curated playlist during your next house party and minimize the visuals and screen brightness.

The new Spotify TV app updates are available to free and premium subscribers using the app on supported Smart TVs, gaming consoles and media streaming devices. The effort to revitalize the user experience on the big screen isn't a huge shocker. Spotify rolled out similar updates for its Desktop app earlier this year in an effort to make streaming more enjoyable when you’re not using your phone.

Daimler has finally started producing its flagship medium-duty electric truck, the Freightliner eM2, in its manufacturing plant in Portland, Oregon. The company didn't say when its first production units will be available but once they are complete, the vehicles will be delivered to select commercial leasing companies in the US and Canada.

The eM2 is powered by a battery-electric Detroit ePowertrain and is designed with 2-speed transmissions that minimize energy cost per mile. The truck’s driving range will depend on the battery capacity per model. The class 6 single-motor version that has a 194 kWh battery can drive up to 180 miles on a single charge. Alternatively, the class 7 dual-motor which is equipped with a 291 kWh battery can drive up to 250 miles on a single charge.

The Freightliner eM2 electric delivery truck, which has been in the works since 2019, was able to be recharged to 200 miles in 60 minutes during testing with Penske. But that test was four years ago, and the company didn’t say anything about recharge times in today’s news. Access to charging stations, like the ones being developed by Penske, will be essential for Daimler’s rollout of the eM2. In a similar regard, Volvo, which contends against Daimler in the EV long-haul trucking space, has been focused on improving the battery ranges of vehicles in its truck fleet. The Volvo FE electric truck, which competes against the eM2, has a range of up to 170 miles and is expected to be out for deliveries in autumn of this year.

Apple’s buy now, pay later system is finally available to all customers in the US after its soft launch back in March. To pay later and begin making equal payments over the course of six weeks, you must be set up on Apple Pay with an eligible debit card.

There is a limit, though. Pay Later only works for purchases that cost between $75 and $1,000 made on iPhone or iPad through a vendor that accepts Apple Pay. The company says during the repayment period you won’t accumulate interest and there are no late fees. However, in the fineprint, Apple says your bank could charge you extra fees “if your debit card account contains insufficient funds to make loan repayments.” After opting to finance a purchase during checkout, your Pay Later loan and payment history gets shared with credit bureaus.

In a video tutorial, Apple breaks down how to start. Simply choose between paying in full through Apple Pay or paying later. If you choose the latter, the tool will automatically tell you how much each payment will cost every two weeks, which is subject to approval. You need to confirm your personal information and ‘Agree & Apply’ before beginning a repayment program.

Apple

Once you start making payments, Apple makes it easy to track your progress. Your total remaining balance, upcoming and previous payments are all laid out through the Wallet app. Here, you can set up autopay and change the bank or debit card you're sourcing your payments from and if you’d like to, tap to pay early. Apple also integrated the calendar tool with the Pay Later feature so that an iPhone user can see everything they owe in a single place to keep tabs on progress.

The introduction of Pay Later puts Apple in competition with other digital repayment apps like Afterpay, Klarna and Affirm, which partnered with big tech giants like Amazon to expand their services. Roughly three in four US iPhone users have activated Apple Pay, according to the Consumer Financial Protection Bureau. The popularity of the company's tap-to-pay tool among iPhone users could help it gain a foothold in this new market.